ESTRO 36 Abstract Book

S752 ESTRO 36 2017 _______________________________________________________________________________________________

related hypertension, 0.60 (0.38-0.95) for preeclampsia, and 0.62 (0.46-0.85) for gestational diabetes. Conclusion For female cancer patients received radiotherapy, the risk of severe postpartum hemorrhage might be increased. EP-1423 the evaluation of sleep quality in cancer patients following the diagnosis of a metastatic site E. Yirmibesoglu Erkal 1 , D. Celik 1 , S. Ozmen 1 , G. Aksu 1 , H.S. Erkal 2 1 Kocaeli University, Department of Radiation Oncology, Kocaeli, Turkey 2 Sakarya University, Department of Radiation Oncology, Sakarya, Turkey Purpose or Objective The aim of this study was the evaluate the sleep quality in cancer patients receiving palliative radiotherapy for the first time following the diagnosis of a metastatic site and to correlate the sleep quality with the depression status and the level of hopelessness. Material and Methods Forty-eight metastatic cancer patients about to receive palliative radiotherapy were evaluated using questionnaires for Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI) and Beck Hopelessness Scale (BHS). There were 12 females and 36 males, their ages ranging from 27 to 77 years (median, 60 years). 39 patients were married and 14 patients had at least high school education. Primary tumor site was listed as the respiratory system in 14 patients and the genitourinary system in 14. The time from the diagnosis of cancer to the diagnosis of the metastatic site was less than 1 month in 17 patients, 1 to 6 months in 10 and over 6 months in 21. Radiotherapy was delivered for bone metastases in 34 patients and brain metastases in 9. Results PSQI scores ranged from 0 to 17 (median, 10) and those with scores over 8 were classified as poor sleepers. BDI scores ranged from 0 to 36 (median, 15) and those with scores over 10 were classified as having mild to severe depression. BHS scores ranged from 0 to 16 (median, 4) and those with scores less than 4 were classified as having no hopelessness at all. Accordingly, there were 30 patients who were poor sleepers, 29 who had mild to severe depression and 25 who were hopeless. There was a strong, positive correlation between PSQI scores and BDI scores which was statistically significant (p=0.002). There was no correlation between PSQI scores and BHS scores. There was a statistically significant association between poor sleep quality and single marital status (p=0.04). Conclusion Self-administered measurements such as PSQI, BDI and BHS might be used as a simple means to collect data on multiple facets of the sleep quality, the depression status and the level of hopelessness. In this study, poor sleepers were prevalent among metastatic cancer patients. Poor sleep, associated with mild to severe depression, deserves adequate medical attention in terms of supportive care EP-1424 Fertility preserving high precision radiotherapy in non-uterine pelvic malignancies in female P.S. Sridhar 1 , N. Madhusudhan 1 , K. Roopesh 1 , J. Vijay kumar 1 , M. Praveen kumar 1 , A. Jerrin 1 , A. Pichandi 1 , B. Ajai kumar 1 1 Health Care Global Enterprises Ltd, Cyberknife- Radiation oncology, Bangalore, India Purpose or Objective Fertility is major issue in non-uterine pelvic malignancies in reproductive age requiring radiation. Primary pathology is most crucial. Malignancies which are potentially curable will always have concern for quality of life and fertility issues. High precision radiotherapy will be able to meet

both ends. In this retrospective study attempt had made to reduce the dose to reproductive organs to preserve the

reproductive functions. Material and Methods

5 cases of non-uterine malignancies of age between 9-30 years who were treated between 2009-2014 were retrospectively analysed.2 were sacral tumors,1 STS of pelvis,1 Ca rectum,1 RMS pelvis. All of them had one or combination of surgery,chemotherapy.All of them were required radiation, 4 of them were treated with Intensity modulated radiotherapy and 1 with cyberknife.

Me an Dos e to ute rus

Age at diagn osis

Dose to prima ry

Reprod uctive functio n

Mean Dose to ovary

foll ow up

Diagn osis

Treatme nt

Chemoth erapy, Bladder preservin g surgery surgery, chemoth erapy

6 year s 6 mon ths 6 year s 4 mon ths 5 year s 4 mon ths 3 year s 8 mon ths 3 year s 5 mon ths

RMS pelvi s

50Gy/ 25Fr IMRT

25G y

9Gy/12 Gy

Menstru ating

9

STS sacru m

66Gy/ 33Fr IMRT

Not Menstru ating

28G y

7.7Gy/ 46Gy

16

STS sacru m

60Gy/ 30Fr IMRT

Surgery 2 times

28G y

7Gy/10 Gy

Deliver ed baby

28

Ca rectu m

Chemoth erapy, surgery

IMRT 60Gy/ 28Fr

28G y

12Gy/9 Gy

Menstru ating

25

30Gy/ 5Fr Cyber knife

STS pelvi s

Surgery, Chemoth erapy

28G y

3Gy/8 Gy

Menstru ating

26

Results Among 5 cases, all are alive, 4 pts (80%) have no disease 1 pt has recurred in postoperative area.4 (80%) patients are having menstruation,1 had delivered healthy baby.1 patient having primary amenorrhoea is treated with High precision radiotherapy in non-uterine malignancies will be able to deliver effective dose to the target, able to achieve within tolerance dose to reproductive organs. In highly selective subset of patients fertility preservation can be attempted. However proper randomised trials in this regard is warranted. EP-1425 Permit to enter no-fly-zone: Risk-adapted mediastinal SBRT for oligometastases safe and effective D. Holyoake 1 , R. Cooke 2 , K. Chu 2 , A. Buckle 2 , M. Hawkins 1 1 CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology- University of Oxford, Oxford, United Kingdom 2 Oxford University Hospitals NHS Foundation Trust, Department of Clinical Oncology, Oxford, United Kingdom Purpose or Objective Stereotactic Body Radiation Therapy (SBRT) to the central chest & mediastinum must be undertaken with caution due to the risks of severe toxicity that may be observed with extreme hypofractionation schedules. A risk-adapted hormones. Conclusion