ESTRO 36 Abstract Book

S580 ESTRO 36 _______________________________________________________________________________________________

(PFS), overall survival (OS), and treatment-related adverse events (AE). Results The matched cohort consisted of 47 HRT and 94 CRT patients with the median follow-up of 27 and 62 months, respectively. Significant higher 5-year LCR and PFS were observed in the HRT group (96% vs. 82% and 96% vs. 76%, p=0.031 and 0.015, respectively). No significant differences in DFFS and OS were observed between groups. Most acute AE included grade 1-2 mucositis, dermatitis, dysphagia and/or hoarseness. Except for one patient who had grade 3 dysphagia in the CRT group, there was no grade 3 or greater chronic AE.

Surgery was the primary modality of management in 120 patients(84.5%).Among them 67 patients (47.2%) had margin positive resection. Most of these were either unplanned excisions or were paranasal sinus lesions. Radiotherapy was delivered to 120 patients (84.5%) as a part of their treatment, with majority being given adjuvant radiotherapy (100 patients). Curative radiotherapy was used in 18 patients. Radiotherapy dose ranged from 60-70 Gy in two Gy equivalent. Recurrence was recorded in 47 patients (33%); 21 patients had isolated recurrence in the primary site, 20 had systemic failure, 5 patients had nodal failure and 1 patient had systemic and local failure. The mean time for development of failure was 32 months (Range 1-99months) for systemic and 44.5 months (Range 5-105months) for loco-regional site. Of the 18 patients who were given radical RT, 14 had complete response (77.7%) and among them eight patients had disease recurrence. Radiotherapy was given to 13 patients with recurrence, eight patients underwent surgery, three patients had chemotherapy and 11 patients were just kept on follow- up. The disease free survival at 5 years was 76.9%. Conclusion Adenoid cystic carcinomas are relatively rare neoplasms of salivary glands. A good proportion of these tumours occur in minor salivary glands as reflected in this analysis. Surgery remains the preferred primary treatment modality with a large proportion of patients also getting RT as a part of their treatment. Along with loco-regional failure, these tumours also have a propensity for distant metastasis. EP-1054 Disease Outcomes following Post-operative IMRT for Oral Cavity Cancer: A Single Institution Analysis A. Michaelidou 1 , M. Lei 1 , T. Guerrero Urbano 1 1 Guy's & St Thomas' NHS Foundation Trust, Oncology- 4th Floor Bermondsey Wing, London, United Kingdom Purpose or Objective The purpose of this study is to analyse survival outcomes in patients with oral cavity squamous cell carcinoma (OCSCC) treated with radical surgery and post-operative IMRT (POIMRT), +/- chemotherapy, at our institution. Material and Methods A retrospective analysis was performed of all patients with OCSCC who received IMRT with radical intent between March 2010 and March 2016. Data were extracted from electronic case records, reviewed only by members of the responsible clinical team. Statistical analysis was done using IBM SPSS and Microsoft Excel. Estimates of overall survival (OS), disease-free survival (DFS) and disease specific survival (DSS) were done using life tables and the Kaplan-Meier method. Results 138 patients with OCSCC received IMRT in total. 127 (73- male, 54-female; mean age-62, range 26-86) were included in the survival analysis. 9 patients unsuitable for surgery that had primary IMRT alone, and one patient who died of aspiration during treatment were excluded. Of the 127 patients analysed, 7 did not complete the prescribed course of POIMRT (patient choice in 3, clinician decision because of toxicity in 4). Most patients had advanced disease on pathological staging: AJCC stage IV - 77.2%, n=98; stage III – 15.7%, n=20; Stage II – 2.4%, n=3; Stage I - 4.7%, n=6. Smoking history was recorded in 124 patients: 64.5%, n=80 reported a significant smoking history (smoking at diagnosis or ex- smokers with >10 pack years). Standard POIMRT doses were 60Gy in 30# (64.6%, n=82) and 65-70Gy in 30-33# (24.4%, n=31) for those with involved margins. Doses of 50-55Gy in 20# were used in

Conclusion This large, single-institutional experience of definitive radiotherapy for ESGC using HRT vs. CRT demonstrates that HRT achieved high rates of LCR and PFS with minimal long-term toxicity. Although these results must be confirmation by randomized controlled study, HRT should be considered for the treatment of ESGC. EP-1053 Analysis of outcomes of Adenoid cystic Carcinoma of Head and Neck region: Single Institution Study M. Rafi 1 , M. Anjanappa 1 , C. Kainickal 1 , P. George 2 , R. Kumar 1 , R. Kunnambath 1 1 Regional Cancer Centre, Radiation Oncology, Trivandrum, India 2 Regional Cancer Centre, Epidemiology and biostatistics, Trivandrum, India Purpose or Objective To study the treatment outcomes of Adenoid cystic carcinoma of the head and neck region. Material and Methods The case records of patients who were diagnosed and treated for adenoid cystic carcinoma of head and neck region in a tertiary care hospital in India between 2004 and 2011 were retrospectively reviewed. Demographic data, clinico-pathological details and treatment outcomes were captured using a structured proforma, for survival analysis and identification of prognostic factors. Results A total of 164 patients reported to the institution with biopsy proven adenoid cystic carcinoma of the head and neck region during this period. Out of this, 142 patients were included in the analysis after excluding the patients who did not undergo any treatment at this centre. Out of the 142 patients analyzed, 57.7% were females. The mean age of presentation was 46.5yrs (Range 16-84 yrs). The most common site of presentation was oral cavity (28.2%) followed by paranasal sinus and nasal cavity (22.5%), and parotid gland (15.5%). A total of 44.4% of patients had stage I /II disease. Node positivity was seen in 16 patients (11.2%) and three patients had metastatic disease at presentation.