ESTRO 36 Abstract Book

S584 ESTRO 36 _______________________________________________________________________________________________

Material and Methods Retrospective comparative study of 125 pts with GC T1 or T0is stage (119 pts) and T2 stage (6 pts) treated with radical intention with radiation therapy in our hospital from June 1995 to June 2015. Hypofractionated treatment (2,25 Gy/fraction; total dose 63 Gy) was used in 42 pts and standard treatment (2 Gy/fraction; total dose 70 Gy) was used in 83 pts. Baseline characteristic were similar in both groups. Median total dose of radiotherapy was 66 Gy (range 63-70). Kaplan-Meier curves have been used for the statistical analysis of survival and the log-rank test for the comparison of the survivals. Treatment-related toxicity was assessed using RTOG and the NCI-Common Terminology Criteria for Adverse Events guidelines. Results The median follow-up was 215 months. The DFS and OS in hypofractionated group were 97,6% and 93% respectively and in standard radiotherapy group were 93% and 95,2% respectively without statistically significant differences. When we analyzed OS by stage subgroups, we can see that in T1 or T0is group the results are better (95,8%) than in T2 group 66,7% (p 0,001) without differences because of the treatment regimen used. In the analysis according to the age of the pts, we had the following results in terms of OS: < 70 years-old pts treated with hypofractionated treatment (28 pts) were 96,4 % and >70 years-old pts (14 pts) were 100%. The OS in < 70 years-old pts treated with standard treatment (43 pts) was 93% and in >70 years-old pts (40 pts) was 92,5% without statistically significant differences. When we analyze OS according to the anterior commissure involvement, we haven´t found statistically significant differences. In both groups the majority of pts had acute skin and mucosa toxicity grade 1-2 without statistically significant differences regardless the regimen of treatment used. Conclusion Hypofractionated treatment supposed better local disease control than standard treatment but in terms of OS there weren´t any differences. When we analized our pts by subgroups stage, we found that T2 stage group had worse results than T1 or T0is stage group in terms of OS (p 0,001) regardless of treatment used. There weren´t no differences in terms of toxicity nor local control between elderly pts and young pts regardless of treatment used either. EP-1063 Epidemiology and clinical outcome of HPV in different head and neck cancer a subgroup analysis E. Boelke 1 , B. Gössler 1 , B. Tamaskovic 1 , W. Budach 1 , C. Matuschek 1 1 University Hospital Düsseldorf Heinrich Heine University Düsseldorf, Radiation Oncology, Düsseldorf, Germany Purpose or Objective Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined disease typically affecting young to middle-aged male non- smokers. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Dusseldorf population. Moreover, among other head and neck regions, a less significant proportion of oral high- grade dysplasia and cancers appears to depend on HPV infection, whereas its role in laryngeal cancer is recognized as less significant. The aim of this study was to find out the incidence and clinical outcome of HPV infection in different head neck cancer patients in a German population. Material and Methods In this retrospective study, the tumour tissue from 164 patients (110 men, 54 women, 62.8 years + 12.7) with head neck cancer (oropharynx = 65 nasopharynx = 10, larynx = 13, hypopharynx = 15, oral cavity = 33 CUP = 5,

Decision Aid Tool (PDA, www.treatmentchoice.info). The goal is help patients to understand treatment options and support clinicians to gain perspective of patients’ preferences. Material and Methods The PDA was validated following the International Patient Decision Aid Standards (IPDAS). First, a prototype was created considering literature and input from an interdisciplinary group. A mixed-method (interview, 5- Likert questionnaire) was used to identify patients’ decisional needs, and to evaluate if the tool was clear and perceived as useful for shared-decision making. Clinicians (N=8) and patients (N= 12) from two hospitals were included. Results Patients and clinicians agreed on patient’s difficulty to recall spoken information and understand risk probabilities. They mentioned the need of information about treatment options, side effects, and effectiveness. Patients asked for information about procedures before and after treatment. Patients preferred information that is simple, visual, and in small chunks. Clinicians preferred information adapted to patient’s psychosocial level. Patients were positive about the PDA. All criteria (satisfaction, effectiveness, clarity, usability, usefulness, intention use) had a median (IQR) of 4 ('agree”). Patients asked for simpler terms, information on psychological effects and the 'no treatment option”. Considering these results, a new version was created (Fig.1). It is a visual tool, containing video interviews with clinicians and animations to explain the treatments. This version will be validated by clinicians and patients for comprehensibility and usability. Results will be considered to create a final version. Thereafter, we will evaluate its impact on shared decision-making in a multi-center setting. Fig. 1: Web-based decision aid tool for advanced larynx cancer patients Conclusion A systematic validation process, as IPDAS, makes it possible to understand the characteristics and decisional needs of patients and clinicians, which are specific and differ among diseases and contexts. This is essential for implementation of PDAs in the clinical practice. EP-1062 Hypofractionated vs standard radical radiotherapy in early (T1-T2) glottic cancer patients. M.A. González Ruiz 1 , J.J. Cabrera Rodríguez 1 , A. Ruiz Herrero 1 , M.C. Cruz Muñoz 1 , P. Simón Silva 1 , J. Quirós Rivero 1 , J.L. Muñoz García 1 , Y. Ríos Kavadoy 1 , M.F. Ropero Carmona 1 , F. García Urra 1 1 Infanta Cristina Hospital, Radiation Oncology, Badajoz, Spain Purpose or Objective To analyze the results [(disease free survival (DFS) and overall survival (OS)] of patients (pts) with glottic cancer (GC) treated with hypofractionated radiation therapy versus standard radiotherapy treatment with radical intention.