ESTRO 36 Abstract Book

S594 ESTRO 36 _______________________________________________________________________________________________

(T1), and at the end (T2) of the RT course. Toxicity was evaluated weekly by CTCAE version 4.0 criteria. Results Fifty patients (36 male and 14 female, mean age 61, range 14-82 years) were included. RT was post-operative in 22 patients (44.0%) and 25 (50.0%) patients received concurrent CT. At T0 evaluation, 32/50 patients (64.0%) were emotionally distressed (cut off value DT score≥4) and 12/50 patients (24%) showed anxiety/depression (cut off value HADS score≥14). No difference was observed according to previous surgery. During RT, patients who were distressed (32/50) or anxious and depressed (12/50) at the beginning of treatment did not show any significant variation of their DT score, while HADS score significantly improved at T2 evaluation (median HADS score 19 and 15, at T0 and T2 respectively, p=0.03). Patients who were not distressed (18/50) or anxious and depressed (38/50) at baseline, showed a worsening of DT score at both T1 (p=0.02) and T2 (p=0.01) as compared to baseline; HADS score remained substantially stable at T1 while worsened at T2 (p=0.03). At T1, 9/40 (22.5%) evaluable patients had G≥3 acute toxicity. Twenty seven/40 (67.5%) patients had significant emotional distress and 9/40 (22.5%) patients had significant anxiety and depression. Emotional distress was more frequently observed among patients who were also experiencing severe toxicity (77.7 versus 22.5% respectively, p<0.01). These patients were also more frequently anxious and depressed (55.5 versus 24.0% respectively, p=0.08). At T2, 10/34 (29.4%) evaluable patients had G≥3 acute toxicity. Twenty five/34 (73.5%) patients had significant emotional distress and 12/34 (35.3%) patients had significant anxiety and depression. No significant difference was observed according to severe toxicity Patients with H&N cancer frequently experience emotional distress and side effects of radiotherapy are stressful and anxiety provoking events. Beside adequate medical support, these patients also require focused psychological interventions. EP-1081 Tumor response after palliative radiotherapy in head and neck cancer and its influence on survival M. Cruz 1 , C. Sousa 1 , D. Branco 1 , L. Khouri 1 , J. Brandão 1 , G. Melo 1 1 Instituto Português de Oncologia de Coimbra, Radiation Oncology, Coimbra, Portugal Purpose or Objective The aim of this study is to evaluate tumor response in Head and Neck (H&N) cancer patients who underwent different fractionation schemes of palliative radiotherapy (RT) and its influence on overall survival. Material and Methods This is a retrospective unicentre study including patients diagnosed with H&N cancer not suitable for curative treatment. Those patients completed palliative radiotherapy to primary local-regional sites in our department between January 2013 and December 2015. Radiation therapy was delivered using a mega-voltage linear accelerator with 6 MV photons. Target volumes generally included the gross tumor volume with 1 to 2 cm margins. Tumor response patterns were evaluated following a cervical and chest Computed Tomography (CT) performed 4-6 weeks after RT. Results 53 patients were included in this study (73.4% male). Mean age was 71.3 years (±1.2). Primary tumor was localized in oropharynx in 34% of the patients, oral cavity in 20.7% and larynx in 18.9% of the patients. 92.4% of the tumors were occurrence. Conclusion

Conclusion Reirradiation in the H&N region with particle therapy gives CBS-rates comparable to normo- or hyperfractionated photon RT, and does not seem to increase in hypofractionated schedules typically used in CIRT, in contrast to what is reported in hypofractionated SBRT with photons. The low number of events does not make it possible to define significant risk factors or tolerance doses for the CA. EP-1080 Psychological distress in patients with head and neck cancer during radiotherapy M. Massaccesi 1 , L. Dinapoli 1 , A. Pesce 1 , R. Autorino 1 , A. Tenore 1 , M. Balducci 1 , D. Smaniotto 1 , G. Chiloiro 1 , M. Rigante 2 , G. Cadoni 2 , G. Paludetti 2 , V. Valentini 1 , F. Miccichè 1 1 Università Cattolica del Sacro Cuore -Fondazione Policlinico A. Gemelli, Radiation Oncology Department- Gemelli ART, Rome, Italy 2 Università Cattolica del Sacro Cuore -Fondazione Policlinico A. Gemelli, Institute of Otorhinolaryngology, Rome, Italy Purpose or Objective The treatment of patients with head and neck (H&N) cancer is usually complex and burdensome. Radical radiotherapy (RT), which may follow surgery and be combined with chemotherapy, usually lasts 6 to 7 weeks and more than half patients can experience relevant acute toxicity. Therefore the experience of receiving RT can be both stressful and anxiety provoking. Aim of this study was to evaluate the psychological distress of patients with H&N cancer during RT. Material and Methods Consecutive patients with H&N cancer who underwent RT with radical intent between January and September 2016 were included in this analysis. Psychological support was available for all patients and Distress Thermometer (DT) and Hospital Anxiety and Depression Scale (HADS) were administered to evaluate emotional distress and mood, respectively at the beginning (T0), after three-four weeks