ESTRO 36 Abstract Book

S597 ESTRO 36 _______________________________________________________________________________________________

chronic toxicities, disease status and overall survival at 2 years were compared between conventional 2DRT and IMRT. Treatment related toxicities were reported using physician rated RTOG acute and late toxicity criteria. Results 58 patients who were treated with conventional 2DRT and 56 patients who were treated with IMRT for locally advanced HNSCC between 2012 and 2014 were chosen for comparative analysis. The 2DRT arm consisted of 45% of stage III and 55% of stage IV patients whereas the IMRT arm had 27% and 73% of them respectively. In the 2DRT arm 53% and 47% had grade 2 and 3 acute mucositis where as in the IMRT arm it was 80% and 5% respectively. This difference reached statistical significance (p<0.001). But, acute skin toxicity was only marginally higher in the 2DRT arm than the IMRT arm. In the 2DRT arm 84% had grade 2 and 3 acute xerostomia while in the IMRT arm it was 45% and this difference reached statistical significance (p=0.004). Likewise, the difference remained statistically significant (p=0.01) with chronic xerostomia evaluated at 1 year post treatment with an incidence of 76% in the 2DRT arm and 38% in the IMRT arm. It was observed that the treatment break due to acute radiation reactions were more in the 2DRT arm (16%) than in the IMRT arm (9%), however this did not reach statistical significance. However, these two modalities showed no significant differences in response to CRT and loco- regional control or survival at 2 years.

superiority over 2DRT with respect to response to CRT, locoregional control and survival at 2 years. EP-1086 Health status and phisical activity in head and neck cancer survivors A. Matías-Pérez 1 , G. Gallego-Herreros 1 , B. G. Díaz de Tudanca 1 , P. Soria-Carreras 1 , A. Nieto-Palacios 1 , A. Rodríguez-Gutierrez 1 , L.A. Pérez-Romasanta 1 1 Hospital Universitario de Salamanca, Radiation Oncology Department, Salamanca, Spain Purpose or Objective Head and Neck (H&N) cancer survivors are an increasingly population, due to the improvement in diagnosis and treatment. The aim of this study is to analyse the health status and physical activity in H&N cancer survivors in a single institution. Material and Methods The population was composed of a series of 50 H&N cancer patients survivors (>3 years post-diagnosis) treated in our institution from 2006 to 2013, having no signs of cancer recurrence to the date. They were reviewed based on personal interviews and specific questionnaires. The health status items measured were: nutritional assessment (with the Body Mass Index (BMI), the Malnutrition Universal Screening Tool (MUST) and the Subjective Global Assessment (SGA)), cardiovascular risk (with the HeartScore® tool), toxic habits (tobacco and alcohol by the Alcohol Use Disorders Identification Test (AUDIT)) and physical activity (with the Global Physical Activity Questionnaire(GPAQ)). Results The mean age was 64 years (range, 43-84 years) and 46 patients (92%) were male. The most frequent site of the primary tumour was larynx (48%) and the main histology squamous cell carcinoma (76%). 72% of patients had advanced cancers (stages III and IV), whereas 26% had stages I and II. All patients received radiotherapy, of which 31 patients (62%) were given 3DRT technique and 19 patients (38%) IMRT technique. Surgery was performed in 17 patients (34%), and 20 patients (40%) underwent neck dissection. The most part of our population had overweight (BMI 27 ± 3). The MUST score showed that 7 patients (14%) were at high risk of malnutrition, and regarding SGA, 12 patients (24%) were suspected of malnutrition. Cardiovascular risk was high or very high in 12 (24%) and 19 (19%) patients, respectively. Taking into account toxic habits, 6 patients (12%) were active smokers, while 38 (76%) were ex-smokers. AUDIT score showed that 3 (6%) were risk drinkers and 3 (6%) had problems related with alcohol abused. 86% of the patients accomplished WHO recommendations of physical exercise. Conclusion Our study indicates that head and neck cancer survivors could have clinical issues regarding health status, and efforts should be done to identify these patients, especially those with risk of malnutrition, high cardiovascular risk or toxic habits, in order to offer the best clinical care. EP-1087 Real-world Cetuximab toxicity in curative and recurrent/metastatic setting in HNSCC patients. I. Desideri 1 , C. Muntoni 1 , C. Ciabatti 1 , M. Lo Russo 1 , P. Bonomo 1 , M. Loi 1 , D. Greto 1 , I. Meattini 1 , L. Livi 1 1 University of Florence, Radiotherapy, Firenze, Italy Purpose or Objective Observational monocentric study to assess, in patients affected by head and neck squamous cell carcinomas (HNSCC), the acute toxicity of Cetuximab (CTX) administered concurrently with radiotherapy (RT) in the curative setting, or as a chemotherapy (CT) in patients with recurrent/metastatic disease.

Conclusion IMRT significantly reduces the incidence and severity of acute mucositis and acute and chronic xerostomia when compared with conventional 2DRT in the treatment of locally advanced HNSCC. However, IMRT did not show