ESTRO 36 Abstract Book

S628 ESTRO 36 _______________________________________________________________________________________________

Figure 2. Variation of red blood cell concentration in irradiated skin of breast cancer patients Conclusion The results showed that radiation-induced microvascular changes in the skin can be objectively measured using novel camera-based techniques before visual changes in the skin are apparent. Also, the proposed methods may be valuable in the comparison of skin reactions between different radiation treatments. EP-1155 Outcomes of breast cancer patients older than 80 years treated with adjuvant radiotherapy R. Barrientos 1 , M. Frelinghuysen 2 , M. Burotto 3 1 Instituto de Radiomedicina IRAM, Radiation Oncology, Concepcion, Chile 2 Hospital Clinico Regional de Concepcion, Radiation Oncology, Concepcion, Chile 3 Clinica Alemana de Santiago, Medical Oncology, Santiago de Chile, Chile Purpose or Objective The main purpose was to estimate surviva l of patients older than 80 years, diagnosed by Stage I-III breast cancer that were treated by surgery and adjuvant radiotherapy with curative intent. Breast cancer specific survival different clinical and pathologic factors that influence survival were estimated. Material and Methods We analyzed 85 breast cancer patients older than 80 years old that received surgery and adjuvant radiotherapy with curative intent. Overall survival was defined as the time from the date histopathological diagnosis until the last date of follow-up (official death certificate). Survival was performed by Kaplan Meier method. A log rank test was used to compare survival of different clinical and pathological factors. Signficance level was determined by (p-value <0.05). Results The median age at the time of diagnosis was 82.7 (range 77 to 88). The median follow up was 42 months. Overall survival was 70% at 5 years. Breast cancer specific survival (BCSS) was 94% a 5 years. Four patients (4.2%) died of cardiovascular disease. Fifty five patients (65%) received partial mastectomy, while 30 patients (35%) received total mastectomy (MT). Fifty four patients (63%) received whole breast or chest wall irradiation, while 31 patients (37%) received locorregional irradiation. Five patients presented cutaneous toxicity grade ≥ 3.In the univariate analysis Clinical preoperative nodes, clinical tumor, locorregional irradiation and pathologic tumor stage were significant for overall survival . No other examined factor was significant.

Conclusion Patients older than 80 treated by Stage I-III breast cancer have long survival after treatment. OS and BCSS is high at five years. Patients with locally advanced preoperatory disease, pathologic tumor size and locorregional irradiation contributed negatively to survival. EP-1156 A clinical trial on hypofractionated whole- breast irradiation after breast-conserving surgery M. Nozaki 1 , Y. Kagami 2 , T. Shibata 3 , K. Nakamura 4 , Y. Ito 5 , Y. Nishimura 6 , Y. Kawaguchi 7 , Y. Saito 8 , Y. Nagata 9 , Y. Matsumoto 10 , T. Akimoto 11 , T. Nishimura 12 , T. Uno 13 , K. Tsujino 14 , M. Kataoka 15 , T. Kodaira 16 , K. Shiraishi 17 , K. Inoue 18 , F. Isohashi 19 , M. Hiraoka 20 , K. Karasawa 21 , S. Izumi 22 , H. Sakurai 23 1 Dokkyo Medical University Koshigaya Hospital, Radiology, Koshigaya, Japan 2 Showa University School of Medicine, Radiation Oncology, Shinagawa, Japan 3 National Cancer Center, Statistical Section- The Japan Clinical Oncology Group Data Center, Chuo, Japan