ESTRO 36 Abstract Book

S748 ESTRO 36 _______________________________________________________________________________________________

Toronto-, Radiation Oncology, Toronto, Canada 2 Universidade Federal de Santa Maria, Radiation Oncology, Santa Maria, Brazil 3 Faculdade de Medicina da Universidade de São Paulo, Radiation Oncology, Sao Paulo, Brazil 4 Princess Margaret Cancer - University of Toronto, Radiation Oncology, Sao Paulo, Canada 5 Instituto do Câncer do Estado de São Paulo ICESP - Faculdade de Medicina da Universidade de São Paulo, Clinical Oncology, Sao Paulo, Brazil 6 Hospital Sírio-Libanês, Radiation Oncology, São Paulo, Brazil 7 Instituto do Câncer do Estado de São Paulo ICESP - Faculdade de Medicina da Universidade de São Paulo, Radiation Oncology, Sao Paulo, Brazil Purpose or Objective Bone metastases cause pain, suffering and impaired quality of life (QOL). Palliative radiotherapy (RT) is an effective method in controlling pain, reducing analgesics use and improving QOL. This study goal was to investigate the changes in QOL scores among patients who responded to RT. Material and Methods A prospective study evaluating the role of radiation therapy in a public hospital in São Paulo-Brazil recorded patients’ opioid use, pain score, Portuguese version of QLQ-BM22 and QLQ-C30 before and 2 months after radiotherapy. Analgesic use and pain score were used to calculate international pain response category. Overall response was defined as the sum of complete response (CR) and partial response (PR). CR was defined as pain score of 0 with no increase in analgesic intake whereas PR was defined as pain reduction ≥ 2 without analgesic increase or analgesic reduction in ≥25% without increase in pain at the treated site. Results From September 2014 to October 2015, 25 patients with bone metastases responded to RT (1 CR, 24PR). There were 8 male and 17 female patients. The median age and ECOG of the 25 patients was 57 years old (range 22 to 89) and 2 (range 0 to 3), respectively. Patient’s primary cancer site was breast (11), prostate (5), lung (2), others (7). For QLQ-BM 22, the mean scores of 4 categories at baseline were: Pain site (PS) 39, Pain characteristics (PC) 61, Function Interference (FI) 49 and Psycho-social aspects (PA) 57. At 2 month follow up, the scores were PS 27, PC 37, FI 70 and PA 59. Statistical significant improvement (p<0.05) was seen in PS, PC, FI but not PA. In the QLQ- C30, the mean scores were not statistically different for all categories, except for pain that demonstrated a 29 point decrease in the pain score domain (69 to 40). Conclusion Responders to RT at 2 month presented improvement in BM22 and C30 pain domains, and also improvement in functional interference if BM22 questionnaire. Patients with painful bone metastases may receive palliative radiation therapy to improve both pain and QOL. EP-1401 SBRT for solitary extracranial metastases from gynecologic malignancies M.C. Repka 1 , N. Aghdam 1 , S. Suy 1 , S.P. Collins 1 , W. Barnes 2 , B.T. Collins 1 1 Georgetown University Hospital, Department of Radiation Medicine, Washington, USA 2 Georgetown University Hospital, Division of Gynecologic Oncology, Washington, USA Purpose or Objective Solitary extracranial metastases from gynecologic malignancies have historically been treated with either surgery or conventional radiation therapy. We report mature local control, toxicity, and survival for patients

was in breast, lung, colorectal and kidney. Performance status of patients was 0-1 according ECOG-scale. All patients have previously radically treated primary tumor and no more than 3-4 distant metastatic lesion by the moment of treatment. Patients receive radiosurgery or hypofractined irradiation in a single dose 6-20 Gy and total summary dose 20-60 Gy by using CyberKhife system. Results In 31 patients with distant metastases in brain, lung, liver, renal and epinephrine after local ablative radiosurgery we registered full tumor regression during 2-6 years. The existence of this group of patients clinically confirms molecular differences between higher and low metastatic potential tumors. That is why previously shown genetic features of oligometastatic tumors change our ideas about possibilities of active local treatment in cases of metastatic disease. Conclusion Thus, our observations clinically confirm the existence of group of patients with oligometastatic tumor disease caused by specific genomic changes in tumor cells. In such cases, local ablative radiosurgery with precision and high doses of radiation could be curative. EP-1399 Rotary-Dual Total Skin Electron Beam Therapy as palliative treatment for mycosis fungoides A. Jodda 1 , M. Pawlaczyk 2 , M. Fundowicz 3 , T. Piotrowski 4 1 Greater Poland Cancer Centre, Medical Physics, Poznan, Poland 2 Poznan University of Medical Sciences, Skin Diseases Prevention, Poznan, Poland 3 Greater Poland Cancer Centre, Radiotherapy, Poznan, Poland 4 Poznan University of Medical Sciences, Electroradiology, Poznan, Poland Purpose or Objective To retrospectively assess the efficacy and toxicity of a total skin electron beam therapy (TSEBT) in patients with primary cutaneous T-cell lymphoma at various stages of development. Material and Methods Treatment results of 40 patients (8 female, 32 male) in median age 60 years (from 40-84 years), with primary cutaneous T-cell lymphoma (mycosis fungoides), stage IB- III, treated between 2001 and 2013 were reviewed. All patients were symptomatic. The median total dose was 32Gy (range 12-40Gy), applied with 1,5 Gy per day four times weekly for the whole skin. Results The median follow-up was 60 months. A clinical complete response was documented in 29 (72.5%) and a partial response in 11 patients (27.5%). The clinical response significantly influenced on the overall survival (OS) (p=0.002) and progression-free survival (PFS) (p<0.001). The mean OS was 76 months. The mean PFS was 48.9 months and the actuarial one-, two- year PFS were 67.5%, 55%. The statistically significant correlation was found between partial and total remission time and the stages of lymphoma (p=0.015). The side effects were observed in all patients during the treatment and include: erythema, skin dryness and desquamation, pruritus, onycholysis and alopecia. Conclusion For palliation of symptomatic cutaneous lymphoma, total skin electron beam therapy is well tolerated and an efficient treatment. EP-1400 Quality of Life in Responders after Palliative Radiation Therapy for Painful Bone Metastases L.C. Mendez 1 , J.L. Padilha 2 , K.M. Lima 3 , E. Chow 1 , F.Y. Moraes 4 , M.D.P.E. Esteves 5 , M.F. Silva 2 , G.N. Marta 6,7 1 Sunnybrook Odette Cancer Centre- University of