ESTRO 36 Abstract Book

S758 ESTRO 36 _______________________________________________________________________________________________

pixels was around 0.3 %. Overlap analysis yielded a mean DC of 0.99 with SD 0.002 which translates in an excellent agreement. HD calculation resulted in a mean distance of 6.02 mm and a SD of 3.42 mm. For all cases the algorithm was able to successfully separate the body from adjacent parts like breathing belt, blankets, mattress etc. (see figure).

reduce RT-related side effects significantly in comparison to sham (false-) acupuncture. Material and Methods A total of 74 patients are to be recruited. In the experimental arm (n=37) an experienced acupuncture- trained person will treat dedicated acupuncture points. In the control arm (n=37) sham-acupuncture will be performed to provide a blinded comparison of results. The Ethics Committee of the Technical University of Munich (TUM) approved the nature and content of the study with the project number 512/15. To evaluate quality of life, patients receive a standardized questionnaire (EORTC QLQ C-30) before their first, after their fourth and after their last acupuncture treatment. Further, a study investigator questions patients about their feelings and symptoms as well as documents detailed information regarding their course of disease. The main endpoint of the trial is the improvement of QoL and reduction of fatigue. Secondary endpoints are the reduction of RT-related side effects such as headache, nausea, and pain. Results The ROSETTA trial is currently recruiting. Initial results from 30 patients (verum acupuncture n=15; sham acupuncture n=15) are presented. All the following items are scaled from 0 to 100. A high score in a symptom scale represents an aggravation of symptoms, whereas a high score in QoL shows an improvement. Concerning nausea/vomiting and QoL no significant difference can be observed between the sham- acupuncture and the verum group. Thus, patients suffer from a constant level of these side effects during RT. From the first examination to the last visit, fatigue increases in the group receiving sham acupuncture (from 21 to 44). Meanwhile, fatigue remains constant in the verum group (from 40 to 40). Verum-acupuncture shows positive effects in reduction of pain (first visit: 21, last visit: 25) in comparison to the sham-acupuncture group (first visit: 23, last visit: 30). Conclusion We present first results of the ROSETTA trial, which show preliminary tendencies in 30 randomized patients. Comparing the verum and the sham-acupuncture group, some differences regarding fatigue and pain are apparent. In spite of undergoing RT, patients in both groups do not feel worse concerning the examined features. Our results and ongoing research will generate an excellent data basis on how to include certain complementary medicine methods into high-end oncology treatment. EP-1419 Optimal design and patient selection for interventional trials using radiogenomic biomarkers D. De Ruysscher 1 , G. Defraene 2 , B. Ramaekers 3 , P. Lambin 4 , E. Briers 5 , H. Stobart 6 , T. Ward 7 , S. Bentzen 8 , T. Van Staa 9 , S. Kerns 10 , C. West 11 1 MAASTRO Clinic, Radiation Oncology, Maastricht, The Netherlands 2 KU Leuven, Radiation Oncology, Leuven, Belgium 3 Maastricht University Medical Center, Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht, The Netherlands 4 Maastricht University Medical Center, GROW School for Oncology and developmental Biology- Department of Radiation Oncology MAASTRO Clinic, Maastricht, The Netherlands 5 Patient Advocate, Patient Advocate, Hasselt, Belgium 6 Patient Advocate, Patient Advocate, Cambridge, United Kingdom 7 Patient Advocate, Patient Advocate, Manchester, United Kingdom 8 University of Maryland, School of Medicine, Baltimore, USA 9 University of Manchester, Manchester Academic Health

Conclusion We have presented a fully automatic algorithm for body delineation on CT that can handle structures adjacent to the patient. It has been evaluated in a clinical setting, showing an outstanding performance. Particularly, 30 clinical cases including several body locations were segmented. Evaluation demonstrated an excellent agreement with respect to reference contours. For segmentation no user interaction is required. Results suggest the suitability of the algorithm for clinical use with cases of the tested region between thorax and pelvis. Future work will explore the use of the algorithm for other body regions. EP-1418 RandOmized Study Exploring the combination of radioTherapy with Two types of Acupuncture treatment R. Asadpour 1 , K. Kessel 1,2 , D. Habermehl 1 , T. Bruckner 3 , S. Sertel 4 , S. Combs 1,2 1 Technical Universy Munich TUM, Department of Radiation Oncology, München, Germany 2 Institute of Innovative Radiotherapy iRT, Department of Radiation Sciences DRS, Neuherberg, Germany 3 Institute of Medical Biometry and Informatics IMBI, Department of Medical Biometry, Heidelberg, Germany 4 Bâtiment hospitalier, Department of ORL and Cervical Surgery, Lausanne, Switzerland Purpose or Objective Acupuncture is known to reduce various clinical signs and symptoms. Often patients treated with radiation therapy (RT) suffer from side effects such as fatigue, nausea/vomiting or reduction of quality of life (QoL). Few randomized data are available to define the role of acupuncture in the context of radiation oncology as a supporting treatment. Therefore, the ROSETTA ( R and O mized S tudy E xploring the combination of radio T herapy with T wo types of A cupuncture treatment) trial was initiated as a prospective randomized phase II trial. It examines if traditional (verum-) acupuncture can