ESTRO 38 Abstract book

S262 ESTRO 38

The vaginal functioning problems dryness, shortening and tightening were significantly correlated with dyspareunia to r=0.407, 0.539, 0.552, respectively (figure 2A-C). The analysis of individual longitudinal pattern revealed 179 patients reporting dyspareunia at least once during FUP (incidence). Of those, the symptom was experienced frequently by 89 (49.7%), but only occasionally by 90 (50.3%) patients, with significant impact on the sexual frequency. 28.1% of patients with frequent dyspareunia showed lower sexual activity (to less than 50% of FUPs). In contrary, only 6.7% of patients with occasional dyspareunia reported a low sexual frequency to the same degree.

Conclusion More than half of locally advanced cervical cancer patients are sexually active after definitive radiochemotherapy plus IGABT. Treatment-induced vaginal changes, such as patient-reported vaginal dryness, shortening and tightening can be associated with pain during intercourse and can impact sexual functioning and frequency. OC-0507 Risk factors for bladder fistula, bleeding and cystitis in cervix cancer: an EMBRACE analysis S. Spampinato 1 , L.U. Fokdal 1 , R. Pötter 2 , C. Haie-Meder 3 , J.C. Lindegaard 1 , M. Schmid 2 , I. Jürgenliemk-Schulz 4 , U. Mahantshetty 5 , B. Segedin 6 , K. Bruheim 7 , P. Hoskin 8 , B. Rai 9 , F. Huang 10 , R. Cooper 11 , E. Van der Steen-Banasik 12 , E. Van Limbergen 13 , K. Kirchheiner 2 , C. Kirisits 2 , K. Tanderup 1 1 Aarhus University Hospital, Department of Oncology, Aarhus, Denmark ; 2 Medical University/General Hospital of Vienna, Department of Radiation Oncology- Comprehensive Cancer Center, Vienna, Austria ; 3 Gustave-Roussy, Department of Radiotherapy, Villejuif, France ; 4 University Medical Centre Utrecht, Department of Radiation Oncology, Utrecht, The Netherlands ; 5 Tata Memorial Hospital, Department of Radiation Oncology, Mumbai, India; 6 Institute of Oncology Ljubljana, Department of Radiotherapy, Ljubljana, Slovenia ; 7 The Norwegian Radium Hospital- Oslo University Hospital, Department of Oncology, Oslo, Norway ; 8 Mount Vernon Hospital, Mount Vernon Cancer Centre, Northwood, United Kingdo ; 9 Postgraduate Institute of Medical Education and Research, Department of Radiotherapy and Oncology, Chandigarh, India ; 10 Cross Cancer Institute and University of Alberta, Department of Oncology, Edmonton, Canada; 11 St James's University Hospital, Leeds Cancer Centre, Leeds, United Kingdom; 12 Radiotherapiegroep Arnhem, Department of Radiotherapy, Arnhem, The Netherlands ; 13 UZ Leuven, Department of Radiation Oncology, Leuven, Belgium