ESTRO 38 Abstract book

S339 ESTRO 38

Collectively, these data indicate that ERG-overexpression is not a predictive marker for the response after RT in PCa but drives a switch to PARP1-EJ which in turn render cells radiosensitized by PARP inhibition. Clinically, this would rationalize the combination of PARP inhibitor olaparib with radiotherapy in ERG-positive PCa patients.

ESTRO 38 Tuesday 30 April