ESTRO 38 - Programme Book & Exhibition Guide

INTERDISCIPLINARY RADIOBIOLOGY CLINICAL BRACHYTHERAPY PHYSICS RTT YOUNG

TUESDAY 30 APRIL 2019

10:09 > Healthy tissue response to a single fraction treatment: Impact of the individual radiosensitivity Speaker: N. Foray (France)

SP-0651

SYMPOSIUM Mechanisms of treatment resistance in glioma 09:15 - 10:30 | Brown 1

In this session, novel insights into glioma resistance and therapeutic opportunities are presented. How glioma stem cells use DNA replication stress to survive, how glioma cells connect and communicate with astrocytes to control their resistance, how glioma cells respond to temozolomide on the transcriptional level to form interaction nodes between sensitive and non-sensitive subpopulations, and how defective signaling pathways in glioma cells can be exploited with novel therapeutic approaches using combinations of radiotherapy plus biologicals are some of the fundamental questions discussed. 09:15 > The role of DNA replication stress in glioma stem cell radiation resistance Speaker: R. Carruthers (United Kingdom), S. Ahmed, K. Strathdee, A. Chalmers 09:33 > Tumor cell connections causing radiation resistance Speaker: F. Winkler (Germany) 09:51 > Transcriptional response to temozolomide in Glioblastoma reveals critical role of long non-coding RNAs 10:09 > Irradiation and targeted inhibition of the PI3K/AKT and MAPK pathways in glioma Speaker: P. Sminia (The Netherlands), R. Narayan, A. Gasol, F. Cornelissen, J. Theys, T. Lagerwei, E. De Vries, F. Bikhezar, A. Denkova, R. De Kruijff, B. Slotman, L. Stalpers, B. Baumert, B. Westerman Speaker: S. Niclou (Luxembourg), S. Fritah, M. Sarmini, W. Jiang, A. Muller, M. Dieterle, R. Mitra, A. Golebiewska, Z. Zhao, F. Azuaje Chair: N. Cordes (Germany) Co-chair: TBC

SP-0652

SP-0653

SP-0654

SP-0655

Programme and Exhibition Guide | SCIENTIFIC PROGRAMME

181