ESTRO Brachytherapy for Prostate Cancer 2018

Radiation proctitis - Chronic • Repopulation of the mucosal cells occurs in the later stage of the acute phase • The severity of the damage to supportive connective tissue

limits the degree of reepithelialization • Fibrosis of the underlying connective tissue causes patchy ischemia of the mucosa, which may cause ulceration • Local trauma or infection often precipitates these ulcers