ESTRO Brachytherapy for Prostate Cancer 2018

Rate of Erection Hardness (ICP) Increases With Increased Pudendal Flow to the Penis

• Electrical cavernous nerve stimulation increases pudendal blood flow and provides rapid increases in intracavernosal pressure (ICP) • Intracavernosal injection of a nitric oxide donor, sodium nitroprusside, produces slow increases in ICP but has no effect on pudendal flow

100

Intracavernosal Pressure (ICP) Pudendal flow

80

60

40

0 200 ICP, mmHg Blood Flow, ml/min 20 0 100

Nerve stim

SNP ic

60s

Illustrates importance of flow-mediated vasodilation in the initiation and maintenance of penile erection in preclinical model

Wayman C et al. ESSM. 4-7 December2005. Poster M-05-141.