ESTRO Multidisciplinary Management of Breast Cancer 2017

Population-based case-control study of major coronary events (MCEs)

• Population: Women irradiated for breast cancer identified from population-based cancer registries (Denmark: 1977-2006, Stockholm: 1958-2002) • 963 Major Coronary Events (MCEs) before breast cancer recurrence identified from nationwide disease registers • 1205 controls also irradiated for breast cancer but without recurrence identified from nationwide disease registers (matched for country, age, calendar period & time since cancer diagnosis)

• Information from oncology records obtained by research nurses (tumor characteristics, medical history, including prior heart disease)

• Individual radiotherapy treatment information obtained by research nurses

NEJM 2013; 368:987-98