ESTRO Multidisciplinary Management of Breast Cancer 2017

Pulmonary toxicity – Interstitial pneumonitis

Complaints: • Pneumonitis/fibrosis, acute pleuritic pain, hypersensitivity • Pulmonary edema, dyspnea, dry cough, fatigue, fever

• Appears gradually over several weeks • Differential diagnosis: Infection, pulmonary embolus, cardiogenic edema, lower ejection fraction, progressive tumor

• Pathology: endothelial cell swelling, necrosis of pneumocytes, generalized fibrosis in end-stage

• Treatment: supportive care, steroids

19-9-2017