ESTRO Multidisciplinary Management of Breast Cancer 2017

Fatigue

‘a distressing, persistend, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion that is not proportional to recent activity and interferes with usual functioning’’

Incidence during treatment 70 – 100%

Chronic fatigue Incidence 0 - 60%* Possible mechanisms: Hormonal dysfunction, dysregulation cytokines, dysruption biorhythm Predictors: depression, pain,poor sleep, menopausal symptoms# More studies are needed to evaluate the burden of this side effect

*Broeckel (1998), Bower(2000), Servaes(2002), Cella(2001) #Lawrence 2004