ESTRO Multidisciplinary Management of Breast Cancer 2017

Less local treatment: discussion

Side effects

• The cumulative toxicity of upfront AI may explain the lack of OS benefit despite improvements in DFS. • Switching from TAM to AI reduces this toxicity and is likely the best balance between efficacy and toxicity.

Hadji P, et al. Breast Cancer Res Treat. 2013;138:185–191