ESTRO Multidisciplinary Management of Breast Cancer 2017

Model parameters for fibrosis found in different studies

n = 0: serial organ n = 1 parallel organ

*

Conclusions: • Dose is the most important predictive factor for fibrosis; • The volume (n) is very small  breast is a serial organ for endpoint fibrosis

* Study of Alexander et al considered to be not representative: also includes mastectomy, techniques outdated, based on studies using different endpoints

Mukesh et al, 2013