ESTRO Multidisciplinary Management of Breast Cancer 2017

BREAST P1: Multicenter randomized phase III trial comparing protons versus standard photon radiation therapy in breast cancer with an indication for regional lymph node irradiation in terms of cardiac toxicity occurrence

 MAIN OBJECTIVE: TO ASSESS THE SUPERIORITY OF THE PROTON LOCOREGIONAL RADIOTHERAPY TO CURRENTLY USED PHOTON- ELECTRONS 3D-CONFORMAL OR INTENSITY MODULATED RADIATION THERAPY (IMRT) IN TERMS OF CARDIAC TOXICITY AT 10 YEARS.

n=1310 patients, open for International participation

SECONDARY OBJECTIVE S :

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 TO SHOW THAT PROTON LOCOREGIONAL RT IS NOT INFERIOR TO CURRENTLY USED PHOTON- ELECTRONS 3D CONFORMAL RT OR IMRT IN EARLY STAGE BREAST CANCER WITH AN INDICATION FOR REGIONAL LYMPH NODE IRRADIATION IN TERMS OF LOCAL-REGIONAL RECURRENCE

 TO ASSESS LOCO-REGIONAL ACUTE AND LATE TOXICITIES (RADIODERMATITIS, ARM MOTION AND FUNCTION, COSMETIC RESULT,

 LUNG AND CONTRALATERAL BREAST EVENTS

 CANCER RELATED-EVENTS: LOCOREGIONAL RELAPSE-FREE SURVIVAL, DISTANT DISEASE-FREE SURVIVAL, OVERALL SURVIVAL, CAUSES OF DEATH,

 TO ASSESS AND COMPARE HEALTH RELATED QUALITY OF LIFE BETWEEN ARMS

TO CONDUCT A COST-UTILITY ANALYSIS

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TRANSLATIONAL RESEARCH

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Interim analysis at 5 years

youlia.kirova@curie.fr

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