ESTRO Multidisciplinary Management of Breast Cancer 2017

PAPBI-2 phase III trial Preoperative Accelerated Partial Breast Irradiation: open in Holland

Inclusion criteria:

Preop PBI vs postop PBI (5 x 5.7 Gy)

Female patients ≥ 51 years cT1-2N0 (≤3 cm) Grade I or II (biopsy)

Endpoint: cosmetic outcome

Side study: tumour response on RT

Histologically proven ductal invasive carcino Unifocal lesion on mammogram and MRI

Hypothesis: fair/poor cosmesis 20%

vs 10%

Exclusion criteria:

Lobular invasive carcinoma Pure DCIS without invasive tumour Triple negative tumours Lymphvascular invasion in biopsy

Aim: 500 patients