ESTRO Multidisciplinary Management of Breast Cancer 2017

Summary: risk on LR and on dying from DCIS

All studies show that: • RT after lumpectomy reduces local recurrences • About 50% of LR are invasive • Risk of dying of breast cancer after DCIS is very low (2-3%) • IF an invasive recurrence develops: risk of dying from breast cancer increases enormously (18 fold acc. to SEER data Narrod et al) • But: preventing invasive LR by RT does not influence breast cancer specific survival…?! 

• Suggestion that RT indeed does improve survival in subgroups •  We need more knowledge on biology, apart from Grade

03/01/13