ESTRO Multidisciplinary Management of Breast Cancer 2017

Positive versus negative margins:

• Housami et al. Ann Surg Onc, 2014

• Large Meta-analysis of 28000 women undergoing BCS for invasive cancer, 1506 local recurrences across 33 studies

• Overall mean LR rate was 5.3% at 79 months

• Relative risk of recurrence 2.44 for positive versus negative margin. Margin width made no difference