ESTRO Multidisciplinary Management of Breast Cancer 2017

Methods

1. Determine residual tumor volume in wide local excision specimens in MARGINs database in relation to distance of invasive primary tumor, i.e. margin width

2. Calculate the TCP (LR) for different residual volumes using Webb- Nahum model

3. Combine 1 and 2 to calculate the LR as a function of margin width

4. Compare the estimated LR with the observed LR rate in the EORTC dataset, as a function of margin width