ESTRO Multidisciplinary Management of Breast Cancer 2017

What happens if you accept focally involved margins ?

Results in the Netherlands:

N = 1078 with focally involved margins

(out of 10.433 patients treated 2003-2008, and of whom resection margins were known (total treated 32.119 patients))

5 yr LR no re-excision + boost: 2.9% 5 yr LR with re-excision +/- boost : 1.1%

 This difference is statistically significant, but clinical relevance doubtful, since:

 No effect on 5 yr DFS and 5 and 10 yr OS

Vos et al, 2017