ESTRO PT 2018

Biological factors

Inherent or acquired tumor cell resistance

Human Ovarian Carcinoma

Mutated tumor suppressors (e.g. p53)

DNA repair gene amplification

Evading cell death (e.g. BCl2, Survivin)

Up-regulation of antioxidative enzymes (e.g. superoxide dismutase, catalase)

Activation of pro-survival oncogenes (e.g. EGFR)