ESTRO PT 2018

CONCLUSIONS (1)

Trials (including randomised)

Model based studies

Series & Registries

Cost - Benefit

Q of Life

Model based studies let optimize the choice of individual cases, but should not be used for recognized indications ( eg eyes, BoS, ped,…) and should have a limit in the number of cases (when a class solution is achieved).

Series and registries, retrospective or prospective, should be promoted, matched with acceptable bias

Clinical trials (randomized or not) are necessary if real Equipoise is proven. In practice, they improve the quality of both arms.

Quality of life and economical data acquisition should be done in all the trials

Trials should be compatible (eg 5 years?) with timing of (technical) evolution of research and control arms , but upgrades and learning during long trial should be possible and can provide useful data anyway.