ESTRO PT 2018

Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer . Liao Z, Lee JJ, Komaki R, Gomez DR, O'Reilly MS, Fossella FV, Blumenschein GR Jr, Heymach JV, Vaporciyan AA, Swisher SG, Allen PK, Choi NC, DeLaney TF, Hahn SM, Cox JD, Lu CS, Mohan R. J Clin Oncol. 2018 Jan 2:JCO2017740720. doi: 10.1200/JCO.2017.74.0720. [Epub ahead of print] Conclusion: proton therapy did not improve dose-volume indices for lung but did for heart. No benefit was noted in grade 3 radiation pneumonitis or local failure (primary endpoints) after proton therapy. Improvements in both end points were observed over the course of the trial.

Pubmed: Komaki lung cancer proton -> more than 20 publications since 2010 showing superiority for proton therapy