ESTRO PT 2018
DNA repair: Non-homologeous endjoining (NHEJ)
Double Strand Break (DBS)
Exposed ends of the DNA strands are detected by the KU70–KU80 heterodimer Fast repair, can be error-prone !!! DNA-dependent protein kinase ( DNA-PKcs ) stabilize broken ends The heterodimer XRCC4/Ligase IV subsequently assists in repairing the break Loss of complete sequences of bases possible
DNA-PK
Ku70
Ku70
Ku80
Ku80
XRCC
Ligase
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