ESTRO PT 2018

Radiation-induced cell communication

Radiation-induced signals transmitted through existing pathways: No radiation-specific pathways ! Signaling in both directions !

growth factors e.g. EGF

death receptor

cytokines e.g.TNF- alpha

Fas-R TRAIL-R

damage-inducible and stress-related proteins

reactive oxygen species (ROS)

cell survival adhesion migration

repair proliferation

NFkB

cytokines for intercellular signaling (TNF α, interleukin 1, 8, TGF ß)

apoptosis

inflammation immunity, survival