ESTRO PT 2018

Radiation damage registration & processing

adapted from: Shilof Y, Nature Reviews, 2003

ionizing radiation

damage recognition

sensors ATM, ATR, SMG1

DNA lesions

amount + type of damage that can be handled

excessive damage, irrepairable

transducer signaling pathways second messengers, tyrosin phosphorylation

activation of the survival response network

activation of the cell death pathway

low fidelity repair

effectors e.g. repairosomes

cell cycle regulation

genetic instability

DNA repair

stress response

malignant transformation

consequences

cell death

cell survival