ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

SCRT + Chemo vs. CRT: Randomized Data

Polish, randomized phase III trial (2008-2014) 515 patients with fixed cT3 or cT4 Two Arms: •

SCRT (5 × 5 Gy) and 3 cycles of FOLFOX4 with delayed surgery • CRT with 5-FU, LV, and oxaliplatin Adjuvant chemotherapy not mandated, 39% received in both Primary endpoint: R0 resection rate Similar compliance and tolerability for each arm R0 resection rates 77% vs. 71% (NS) and pCR 16% versus 12% (NS) Lower acute toxicity with SCRT, similar post-op and late complications

ESTRO IG and Adaptive Course Parikh Budapest 2018