ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

HYBRID study

Hy pofractionated B ladder R adiotherapy with or without I mage guided a D aptive planning

• A multicentre randomised phase II study (36Gy in 6f)

RANDOMISE

1:1

Group 2: Adaptive planning (experimental) Planning CT scan post void. CTV: whole bladder plus any area of extravesical spread.

Group 1: Standard planning (control)

Planning CT scan post void. Clinical target volume (CTV): whole bladder plus any area of extravesical spread. One 3D conformal plan will be generated with 1.5cm expansion margin.

Three 3D conformal plans will be generated: 1. Small; 2. Medium; 3. Large

Pre-treatment Cone Beam CT will be used to verify CTV coverage.

Pre-treatment Cone Beam CT will be used to select appropriate plan, this will be confirmed by a second trained observer.

29

Chief Investigator Prof Robert Huddart