ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

DW-MRI to inform tumour boost

Individual change in tumour bed volume

110

Mean conventional GTV was 31.0 cm 3 (range 6.7-78.7cm 3 ). Mean DW-MRI GTV was 16.1cm 3 (range 0-35.3cm 3 ). There was significant reduction in GTV using DW-MRI (p=0.002).

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Anatomically defined tumour bed

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DW-MRI defined tumour bed

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Tumour voulme (cm3)

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Acquiring DW-MRI for radiotherapy

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planning may complement target volume delineation and inform non- uniform dose delivery to biological sub-volumes for bladder radiotherapy dose escalation trials.

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Patient

Hafeez et al., Characterisation of tumour boost with diffusion weighted MRI (DW-MRI) to inform biological target volume for radical radiotherapy in muscle invasive bladder cancer (MIBC) NCRI 2015.