ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

Estimate pattern of spread from response to incidental dose in clinical trial data (high risk prostate patients)

Average dose no failures – average dose failures

≈ 7 Gy p = 0.02

-

=

PSA controls

PSA failures

1.0 100%

≥ median

0.8 80%

0.6 60%

0.4 40%

< median (53.1 Gy)

0.2 20%

Free from any failure

Treatment group IV, Hospital A (n=67) p = 0.000

0.0

0%

0 0

12

24

36 3

48

60

72 6 Y

Witte et al, IJROBP2009; Chen et al, ICCR2010