ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

RTOG 0617 – Dose escalation

Local failure rate at 18 months post-treatment:

60 Gy

74 Gy

25.1%

34.4%

Does this make sense?

Reasons?

Minimum margin was smaller in the high-dose group (mean 4·5 mm [2·9] in the standard-dose group vs 3·9 mm [3·0] in the high-dose group; p=0·0047)

Bradley et al., Lancet Oncology 2015

03/01/13