ESTRO meets Asia 2024 - Abstract Book

S2

Invited Speaker

ESTRO meets Asia 2024

Abstract

Radiation therapy treatments have seen a shift toward hypofractionation with promising patient outcomes being observed in recent studies. With increasingly conformal radiation delivery techniques and higher doses being delivered with smaller margins, the need for strategies that mitigate treatment uncertainties resulting from the dynamic nature of human anatomy is greater now more than ever. While motion management strategies have existed in some form for more than two decades, further developments have seen adaptation being performed on increasingly shorter time scales and with a variety of treatment systems and strategies. X-ray imaging of fiducial markers has commonly been used to guide tracking with markerless approaches also emerging to eliminate the need for marker implantation. Combined MR-linac systems have also been implemented clinically to provide high quality soft tissue imaging during radiation delivery. These motion monitoring methods are often used to guide gating, but motion can also be adapted to using MLC tracking or robotic and gimbaled linacs. The field has recently seen a growing presence of machine learning techniques being applied to monitor and adapt to motion. These methods have allowed for improved tumour targeting across a range of treatment sites including the prostate, lung, and liver. There are however still a number of technical and practical barriers to be overcome to enable widespread clinical implementation.

470

Statistics for outcome modelling/radiomics (/trials)

Ivan R Vogelius

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Dept of Oncology, Rigshospitalet, Copenhagen, Denmark

Abstract

In this teaching lecture we will start by the basic methods of statistical inference. We will then quickly move on to discuss examples of outcome analyses in radiation oncology within both a physics-oriented questions, e.g. dose response or clinical outcomes such as survival. We will, of course, talk about the reproducibility crisis and how to best counter it and contribute to better research in the field.

471

SGRT implementation and clinical outcomes

Bartosz Bak

Radiotherapy Department II, Greater Poland Cance Center, Poznan, Poland. Electroradiology Department, University of Medical Science, Poznan, Poland

Abstract