ESTRO meets Asia 2024 - Abstract Book

S106

Interdisciplinary – CNS

ESTRO meets Asia 2024

Department of Radiotherapy, Prof.dr.I.G.N.G. Ngoerah General Hospital, Denpasar, Indonesia

Purpose/Objective:

To study the incidence and overall survival of pediatric patients with central nervous system malignancy undergoing radiotherapy at Prof. dr. I.G.N.G. Ngoerah General Hospital from 2021 to 2023

Material/Methods:

This study is a retrospective cohort, utilizing data from medical records, to study the incidence and overall survival of pediatric patients with central nervous system undergoing radiation therapy at Prof. dr. I.G.N.G. Ngoerah General Hospital from 2021 to 2023.

Results:

The study comprised of 12 pediatric patients, predominantly male (75%), with an average age of 15 ± 3.73 years (range: 4–17). Common tumor types included medulloblastoma (41.7%), glioblastoma (16.7%), Ependymoma (16.7%). The 10–14 age group was most represented (41.7%). Overall survival stood at 58.3%, with astrocytoma (100%), germinoma putamen (100%) and meningioma (100%) exhibiting the highest survival rates, while glioblastoma (0%), ependymoma (50%), and medulloblastoma (60%) displayed the lowest rates. Multivariate analysis revealed no significant association between age at diagnosis, tumor type, and survival.

Conclusion:

In conclusion, this study provides valuable insights into pediatric tumor epidemiology and survival. However, limitations such as the short follow-up period and small sample size may affect the generalizability of the findings and might not fully capture long-term survival trends. Further research with larger samples and longer follow-up periods is needed to fully understand pediatric oncology and improve patient outcomes.

Keywords: pediatric, radiotherapy, radiation therapy

References:

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Heath, J.A., Zacharoulis, S., Kieran, M.W. (2012), Pediatric neuro-oncology: Current status and future directions. Asia-Pacific Journal of Clinical Oncology , 8: 223-231. https://doi.org/10.1111/j.1743-7563.2012.01558.x

Louis, D.N, Perry, A., Wesseling, P., Brat, D.J., Cree, I.A., et al . (2021). The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology , 23(8), 1231–1251. https://doi.org/10.1093/neuonc/noab106

Ostrom, Q. T., Price, M., Ryan, K., Edelson, J., Neff, C., Cioffi, G., Waite, K. A., Kruchko, C., & Barnholtz-Sloan, J. S. (2022). CBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and