ESTRO meets Asia 2024 - Abstract Book

S107

Interdisciplinary – CNS

ESTRO meets Asia 2024

Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018. Neuro-oncology, 24(Suppl 3), iii1–iii38. https://doi.org/10.1093/neuonc/noac161

Udaka, Y. T., Packer, R. J. (2018). Pediatric Brain Tumors.

Neurologic clinics , 36(3), 533–556.

https://doi.org/10.1016/j.ncl.2018.04.009

Williams, L.A., Hubbard, A.K., Scheurer, M.E., Spector, L.G., Poynter, J.N. Trends in paediatric central nervous system tumour incidence by global region from 1988 to 2012. (2021). International Journal of Epidemiology , 50(1), 116–127. https://doi.org/10.1093/ije/dyaa176

193

Digital Poster

Ferroptotic genes identifies multiple susceptibility loci on GBM efficacy in Taiwanese population

Yi-Hsuan Lai 1 , Jang-Chun Lin 1 , Wei-Hsiu Liu 2

1 Radiation Oncology, Shuang Ho Hospital, New Taipei City, Taiwan. 2 Neurological Surgery, Tri-Service General Hospital, Taipei, Taiwan

Purpose/Objective:

Gliomas are a type of malignant brain tumor that often spreads diffusely throughout the brain. In Taiwan, gliomas are the most common primary malignant tumors of the central nervous system. There are two major grades of gliomas: glioblastoma (GBM) and astrocytoma, with GBM having a particularly poor prognosis. Ferroptosis is a newly discovered form of regulated cell death that involves the iron-dependent accumulation of lipid hydroperoxides, leading to oxidative damage and cell death. Recent studies have shown that ferroptosis, a newly discovered form of regulated cell death, plays a crucial role in the resistance of GBM to chemotherapy, especially with the drug temozolomide (TMZ). Given this, we conducted research to investigate the potential role of ferroptosis in brain tumors in Taiwan. The project's goal is to establish a comprehensive database comprising clinical data and genetic profiles of one million participants. The recruitment process involved enlisting participants from medical centers, and their genotyping was performed by Academia Sinica. The SNP array utilized in this Taiwan Precision Medicine Initiative (TPMI) project is a modified version of the Axiom Genome-Wide (Taiwan Biobank) TWB 2.0 Array Plate. It is specifically designed to analyze around 130 thousand known risk variants, 580 thousand mapping SNPs, and 20 thousand copy number variant markers. Participants were assigned to either the case or control group based on the ICD records (International Classification of Diseases) and SOAP (The Subjective, Objective, Assessment, and Plan) notes provided by the hospital. The study enrolled a total of 1050 participants, consisting of 311 glioma cases and 739 normal participants. Here, we investigated the potential role of ferroptosis in GBM patients. First, we provided a basic definition and explanation of ferroptosis, highlighting its involvement in iron metabolism and lipid peroxidation. We also noted that GBM patients often experience anemia, which may be related to alterations in iron homeostasis. Next, we conducted a high-throughput analysis combining Genome-wide association study (GWAS) and clinical patient data to identify ferroptosis-related genes that are significantly linked to GBM. Based on the GSE50161 study, we Material/Methods: