ESTRO meets Asia 2024 - Abstract Book

S109

Interdisciplinary – CNS

ESTRO meets Asia 2024

Conclusion:

Overall, our findings suggest that ferroptosis-related genes, especially STEAP3 and CP, may play a crucial role in developing and progressing brain tumors in Taiwanese patients. Further exploration of these genes' mechanisms may lead to potential prognostic markers and therapeutic targets for brain tumors in the future.

Keywords: Ferroptosis, GBM, SNP

204

Digital Poster

State of the art of hippocampal-avoidance radiotherapy implementation in cancer centers in Vietnam

Basma MBAREK 1 , Ha THU Huynh Nguyen 2 , Tin phang duc 1 , thao vo 1

1 oncology, FV hospital, HCMC, Vietnam. 2 oncology, FV hospital, hcmc, Vietnam

Purpose/Objective:

Brain metastasis (BM) is a poor prognosis event in the evolution of cancer. During the last decade the indications of whole brain radiotherapy have greatly reduced favoring stereotactic radiosurgery (SRS) techniques. The access to radiosurgery is limited in Vietnam with only two gamma-knife machines for almost 100 million population. Thus whole brain radiotherapy is still indicated in patients with numerous brain metastasis, those that can not access SRS and cases with meningeal invasions. Using Hippocampal avoidance (HA) has been proven to reduce the neurocognitive complications of whole brain radiotherapy. Implementing this technique needs access to MRI imaging and fusion modules, as well as a learning curve for hippocampal contouring and for planning with IMRT/VMAT techniques. This treatment is also more time consuming than simple 3D whole brain radiotherapy. The aim of this study is to evaluate the state of the art of implementation of this HA technique in the Vietnamese radiotherapy centers and find out about the roadblocks that would hinder its implementation in daily practice as standard of care when indicated.

Material/Methods: