ESTRO meets Asia 2024 - Abstract Book

S112

Interdisciplinary – CNS

ESTRO meets Asia 2024

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The Efficacy and Safety of Radiotherapy on Patients with Atypical Meningioma: A Systematic Review"

Mikael Harkingto Wibisono 1 , Maria Georgina Wibisono 1 , Jacobus Jeno Wibisono 2

1 Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia. 2 Department of Obstetric and Gynecologic Medicine, Pelita Harapan University, Tangerang, Indonesia

Purpose/Objective:

Atypical Meningiomas (AMs), classified as WHO grade II tumours, are responsible for up to 30% of all meningioma cases. It grows at a faster rate with a higher risk of recurrence in comparison to typical meningiomas. Through various studies, professionals have partnered to understand the best treatment possible. Radiotherapy, a widely utilized treatment in cancer management, uses X-ray radiation to destroy abnormal cells. However, there are still uncertainties whether Radiotherapy results are favorable or safe to be used in daily practice. Thus, we analyze the effects of various Radiotherapy (IMRT, mRS, PRRT, Hypofractionated Stereotactic RT, and Stereotactic RT) on Progression-Free Survival (PFS), Overall Survival (OS) and LC (Local Control) in patients with AM. Data was collected from Pubmed, ScienceDirect, and PMC using MeSH keywords “Meningiomas” and “Radiotherapy” on February 15, 2024. Exclusion criterias were animal studies, incomplete outcome reporting, studies not available in English, irretrievable full-text articles, and irrelevant studies. Inclusion criterias were patients with atypical meningiomas, Randomized Controlled Trial (RCT) studies within 5 years, and radiotherapy (IMRT, mRS, PRRT, Hypofractionated Stereotactic RT and Stereotactic RT) as intervention. All studies measured the Progression-Free Survival (PFS), Overall Survival (OS), Local Control (LC) and the quality of included studies were assessed using Jadad Scale. Material/Methods:

Results:

Nine out of fifteen studies with a total patients of 13.429 were eligible. 7 studies showed high quality and two studies were moderate. 7 studies had shown radiotherapy to be effective for patients with Atypical Meningiomas. Two studies had shown major adverse effects (dizziness and fatigue) and one study had shown minor adverse effects (mild transient hematoxicity) to some patients treated with radiotherapy. In addition, radiotherapy showed high Progression-Free Survival (PFS), Overall Survival (OS) and Local Control (LC).

Conclusion:

In conclusion, radiotherapy provides a satisfactory treatment option in terms of its efficacy and safety for patients with Atypical Meningioma. To ensure this, further studies are needed to view significant differences for treatment related adverse effects in patients treated with radiotherapy.

Keywords: Meningioma, Radiotherapy