ESTRO meets Asia 2024 - Abstract Book

S156

Interdisciplinary – Haematology

ESTRO meets Asia 2024

The average treatment planning time was 5 days and the average treatment delivery time were 140 minutes for first fraction and 74 minutes for the last fraction. The average treatment planning time and radiation treatment delivery of subsequent patients were reduced with the experience gained (Figure 2).

The mean isocentre shifts detected for isocentre 1 (head) were x= +0.10 cm, y= -0.08cm, z= -0.11cm, at isocentre 2 (thorax) were x= +0.11cm, y= +0.01cm, z= -0.05 cm, at isocentre 3 (abdomen) were x= -0.03cm, y= +0.18cm, z= +0.23cm and at isocentre 4 (pelvis) were x= +0.05cm, y= +0.03cm, z= +0.03cm.

There were no grade 3-4 toxicity reported. There was one death due to transplant related haemophagocytic lymphohistiocytosis.

Conclusion:

Total body irradiation with VMAT technique using a standard linear accelerator is possible with minimal additional accessories. With experience, planning and treatment delivery time can be reduced after a period of troubleshooting. Meticulous planning and timely communication between the radiation team members and referring physicians are necessary to streamline the TBI delivery process.

Keywords: total body irradiation, VMAT

References:

1. Peters C, Dalle JH, Locatelli F et al. Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study. J Clin Oncol . 2021 Feb 1;39(4):295-307.