ESTRO meets Asia 2024 - Abstract Book

S179

Interdisciplinary – Head & neck

ESTRO meets Asia 2024

Significant weight loss in mice was observed starting from the eighth day of irradiation, reaching its nadir on the eleventh day, followed by gradual recovery. The period from day 8 to day 11 was defined as the acute RIOM phase. Mass cytometry analysis of tongue mucosa from both irradiation and control groups during this period revealed a marked increase in the proportion of B cells within the CD45-positive cell population in the irradiation group. Concurrently, CD4+ and CD8+ T cells exhibited an upward trend. Conversely, neutrophils, eosinophils, classical dendritic cells (cDC), plasmacytoid dendritic cells (pDC), and γδT cells displayed a decreasing trend. Throughout this process, the percentage of macrophage populations showed no significant change.

Figure 1. Mouse Weight Curve

Figure 2. Mass Cytometry Analysis of Tongue Mucosa

Conclusion:

Our study has explored the immunological infiltration dynamics during the onset and development of RIOM. We observed that radiotherapy led to a decrease in mouse body weight, concomitant with changes in immune cell populations within the tongue mucosa. These findings underscore the regulatory mechanisms of the immune system, particularly emphasizing the significant roles played by B cells and T cells during the onset of RIOM. This research provides a foundational understanding for future investigations, with the potential to advance the development of more effective therapeutic strategies for RIOM, thereby improving the quality of life for affected patients.

Keywords: Oral Mucositis, immune microenvironment

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