ESTRO meets Asia 2024 - Abstract Book

S189

Interdisciplinary – Head & neck

ESTRO meets Asia 2024

(hazard ratio [HR] 3.87, 95% Confidence interval [CI]: 1.52-9.87, p<0.01) in multivariate analysis. For LEDFS, significant factors were PS, hypopharyngeal extension and clinical stage in univariate analysis and hypopharyngeal extension (HR 2.38, 95%CI: 1.12-5.03, p=0.02) and clinical stage (HR 4.07, 95%CI: 1.48-11.06, p<0.02) in multivariate analysis. Metachronous esophageal cancer incidence was 28.6% at 5 years. Severe late toxicities included grade 3 pneumonitis, esophageal stricture, esophageal fistula, laryngeal stricture, and laryngeal edema were observed in 1 (2%), 1 (2%), 4 (2%), 1 (2%) and 1 (2%) patient, respectively. Grade 2 hypothyroidism was observed in 31 (53%) patients.

Conclusion:

This study provides a comprehensive analysis of the locoregional control, survival outcomes, and toxicities in patients with cervical esophageal cancer treated with chemoradiotherapy. LEDFS showed the survival curves that reflected laryngo-esophageal function from early to long after treatment. The prognostic factors for LEDFS by multivariate analysis were hypopharyngeal extension and clinical stage. We believe that LEDFS will be one method of survival analysis that takes into account the quality of life after chemoradiotherapy for patients with cervical esophageal cancer.

Keywords: cervical esophagus, chemoradiotherapy, LEDFS

397

Proffered Paper

Treatment outcomes of swallowing sparing VMAT in HPV negative Head and Neck Carcinoma patients.

Aman Sharma, Yousra Izzuddeen KN, Tenzin Choden, Adrija Ghosh, Abhilash Dagar, Sangeeta Hazarika, Jaswin Raj, Karun Kamboj, Supriya Mallick, Daya Nand Sharma

Radiation Oncology, National Cancer Institute, Jhajjar, India

Purpose/Objective:

Recently swallowing sparing IMRT has been established as a new standard of care for radical Head and neck carcinoma (HNC) patients. 1 At present there is limited data available on swallowing sparing IMRT for HPV negative HNC that predominates the Asian subcontinent. The objective of present study is to evaluate treatment outcomes and organ sparing achieved in HPV negative tumors.

Material/Methods:

In the present study, all HNC treated with radical CRT/RT from August 2020 - December 2023 were included. All patients were discussed in multidisciplinary tumors board where conjoint decision were taken by team compromising of radiation oncologist, medical oncologist, head and neck surgeons and surgical oncologists. Gross tumor volume (GTV=GTV_primary+GTV_Nodes) delineation included clinically/radiologically (including PET scan) apparent disease. For primary tumor (GTV_P) margin of 0.5 cm generated CTV_P1 and 1 cm margin generated CTV_P2. CTV_LN encompassed microscopic disease to regional lymphatics at risk. A 5 mm margin generated the planning target volume. The dysphagia & aspiration related structures (DARS) delineated included superior, middle, inferior constrictor muscles, base of tongue, supraglottic larynx, larynx, cricopharyngeus muscle,