ESTRO meets Asia 2024 - Abstract Book

S221

Interdisciplinary – Mixed sites/palliation

ESTRO meets Asia 2024

Figure 2. Intracranial control curve in treatment planning method group A and B

Conclusion:

Dose escalation technique with simultaenous integrated boost is safe and effective for brain metastases cases. However, further validation of its clinical benefits is required through a larger study involving a more extensive patient population and longer follow-up.

Keywords: brain metastases, radiotherapy, escalated doses

References:

1. Rodrigues G, Yartsev V, Roberge D, MacRae RM, Roa W, Panet-Raymond V, Masucci L, Yaremko B, D'Souza DP, Palma DA, Sexton T. A phase 2 multi-institutional clinical trial assessing fractionated simultaneous in-field boost radiation therapy for brain oligometastases. International Journal of Radiation Oncology, Biology, Physics. 2015 Nov 1;93(3):S39. 2. Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. The Lancet. 2004 May 22;363(9422):1665-72.

3. Ni L, Liang X. Feasibility of simultaneous integrated boost with forward intensity-modulated radiation therapy for multiple brain metastases. Contemporary Oncology/Współczesna Onkologia. 2014 May 1;18(3):187-91.

4. Ferro M, Chiesa S, Macchia G, Cilla S, Bertini F, Frezza G, Farioli A, Cammelli S, Balducci M, Ianiro A, Angelini AL. Intensity modulated radiation therapy with simultaneous integrated boost in patients with brain oligometastases: A phase 1 study (ISIDE-BM-1). International Journal of Radiation Oncology* Biology* Physics. 2017 Jan 1;97(1):82 90. 41. Dobi Á, Fodor E, Maráz A, Együd Z, Cserháti A, Tiszlavicz L, Reisz Z, Barzó P, Varga Z, Hideghéty K. Boost irradiation integrated to whole brain radiotherapy in the management of brain metastases. Pathology & Oncology Research. 2020 Jan;26(1):149-57.