ESTRO meets Asia 2024 - Abstract Book

S238

Interdisciplinary – Other

ESTRO meets Asia 2024

radiotherapy (RT) course without prolongation of the overall treatment time (OTT) beyond 2 days.3 The present audit in aimed to evaluate OTT and compliance for radically treated HNC patients in the era of IMRT.

Material/Methods:

All radically treated patients between January 2020 and December 2023 were included in the study. Locally advanced patients were treated with concurrent chemoradiotherapy compromising of weekly cisplatin of 40mg/m 2 whereas early-stage patients were treated with radical radiotherapy alone. Patients were evaluated for age, site, gender and stage at presentation. All patients were planned SIB IMRT of 66Gy, 54Gy in 30 fractions. Patients with N3b nodes were treated with 70 Gy in 30 fractions. Non-compliance to cancer-directed therapy (CDT) was defined as patients who were unable to finish the stipulated treatment course. OTT was calculated from the date of start of RT to the date of completion. As regards to study pattern of gaps introduced between treatment, patients were stratified as OTT prolongation less than 2 days, OTT prolongation 2-5 days and OTT prolongation beyond 5 days.

Results:

A total of 339 patients were included in the audit. Majority (89%) of all the patients were males. Median age was at diagnosis was 60 years (51-67years). The most common site of primary was Oropharynx (60.2%). Eighty-four percent of the patients presented in loco-regionally advanced (stage III and IV patients). The majority of the patients (92%) were able to complete the stipulated treatment course whereas 8% of the patients could not complete the treatment. The median OTT was 43 days (IQR 41-46 days). Fifty-seven percent of the patients completed treatment without prolongation of OTT beyond 2 days (total 44 days), while in 15% of patients, there was prolongation of OTT of 2-5 days. In 20% of the patients, there was prolongation OTT beyond 5 days. Acute grade 3 or higher toxicities were noted in 34.1% of patients.

Conclusion:

In our audit, 8% of the patients were non-compliant with CDT. In every one out of five patients, there was prolongation of OTT beyond 5 days. Results from our study lay emphasis on the continuity of a course of radical radiotherapy for HNC patients.

Keywords: OVERALL TREATMENT TIME, COMPLIANCE TO TREATMENT

References:

1. Bese NS, Hendry J, Jeremic B. Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation. International Journal of Radiation Oncology* Biology* Physics. 2007 Jul 1;68(3):654-61.

2. Taylor JM, Withers HR, Mendenhall WM. Dose-time considerations of head and neck squamous cell carcinomas treated with irradiation. Radiotherapy and oncology. 1990 Feb 1;17(2):95-102.

3. Sharma A, Jagadesan P, Chaudhari P, Das S, Bhaskar S, Thakar A, Sharma A, Mohanti BK. Six ‐ year analysis of compliance to weekly concurrent chemoradiotherapy in head and neck carcinomas. Clinical Otolaryngology. 2016 Oct;41(5):442-7.