ESTRO meets Asia 2024 - Abstract Book

S241

Interdisciplinary – Paediatric tumours

ESTRO meets Asia 2024

353

Digital Poster

Pediatric Nasopharyngeal Carcinoma: Unveiling the Role of IMRT through a Systematic Review

Lusi Tania Rahmartani, Henry Kodrat

Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Purpose/Objective:

Nasopharyngeal cancer (NPC) in childhood is a rare case, and the treatment has been primarily based on adult NPC due to limited data. However, the use of intensity-modulated radiation therapy (IMRT) has emerged for treating pediatric NPC, offering better tumor control while minimizing exposure to healthy tissues. This study aims to know the efficacy and toxicity of IMRT in pediatric NPC.

Material/Methods:

A comprehensive search was conducted across PubMed, Embase, Scopus, and Cochrane databases spanning from their origins to December 15, 2023. Relevant research comparing oncologic outcomes for pediatric NPC between Conformal Radiation Therapy (CRT) and IMRT was incorporated into the analysis.

Results:

248 articles screened, identifying five relevant studies. IMRT demonstrated superior 2-year locoregional control, disease-free, and overall survival rates in pediatric NPC, accompanied by a substantial reduction in acute Grade 3 dermatitis, mucositis, and dysphagia. Notably, IMRT holds promise in mitigating long and impressive 82.6% - 93% in 3-year overall survival rate, with lower rates of acute Grade 3 toxicities. However, long-term morbidity data needs to be further validated.

Conclusion:

IMRT showed excellent results in pediatric NPC population, linear with the results from the adult group. Treatment with induction chemotherapy followed by concurrent chemo-radiotherapy (CCRT) with IMRT are preferred in pediatric NPC and could be the standard of choice in radiotherapy technique. Further research is required to ascertain the treatment scheme and dose in pediatric NPC.

Keywords: pediatric, NPC, IMRT

References:

1. Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA. Cancer J. Clin. 71 , 209–249 (2021). 2. Ayan, I., Kaytan, E. & Ayan, N. Childhood nasopharyngeal carcinoma: from biology to treatment. Lancet Oncol. 4 , 13–21 (2003). 3. Mertens, R. et al. Nasopharyngeal carcinoma in childhood and adolescence. Cancer 80 , 951–959 (1997).