ESTRO meets Asia 2024 - Abstract Book

S248

Interdisciplinary – Particle Therapy

ESTRO meets Asia 2024

Conclusion:

Proton based IMPT can significantly reduce volume receiving low to medium level radiation dose upto 40Gy for all OARs with similar or better target coverage. This may potentially result in a reduction in clinical toxicities as noted with IMRT planning.

Keywords: proton therapy, anal canal cancers, IMPT

References:

1. Wo, J. Y. et al. Pencil Beam Scanning Proton Beam Chemoradiation Therapy With 5-Fluorouracil and Mitomycin C for Definitive Treatment of Carcinoma of the Anal Canal: A Multi-institutional Pilot Feasibility Study. Int J Radiat Oncol Biol Phys 105, 90–95 (2019). 2. Meier, T., Mascia, A., Wolf, E. & Kharofa, J. Dosimetric Comparison of Intensity-Modulated Proton Therapy and Volumetric-Modulated Arc Therapy in Anal Cancer Patients and the Ability to Spare Bone Marrow. International Journal of Particle Therapy 4, 11–17 (2017).

3. Ojerholm, E. et al. Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity modulated radiotherapy. Acta Oncol 54, 1209–1217 (2015).

4. Semerenko VA, Reitz B, Day E, Qi XS, Miften M, Li XA. Evaluation of a commercial biologically based IMRT treatment planning system. Med Phys. 2008;35:5851–60.