ESTRO meets Asia 2024 - Abstract Book

S295

Interdisciplinary – Urology

ESTRO meets Asia 2024

age, PSA at diagnosis, clinical T stage, ISUP Grade Group, jurisdictions, area of residence (metropolitan, inner regional, outer regional/ remote), socioeconomic status (SES, divided into quintiles), and treatment centres (public/ private). Multivariable logistics regressions were used to identify covariables associated with ADT use. All analyses were performed separately for IRPC and HRPC.

Results:

There were 14,610 men included in this study, of which 8,611 (59%) had ADT with RT – 40% (2,870/7,054) in IRPC, and 76% (5,741/7,556) in HRPC. There were large variations in ADT use between jurisdictions, ranging from 22% to 73% for IRPC (P<0.001) and 56% to 92% for HRPC (P<0.001). Men living in regional/remote areas were more likely to have ADT with RT compared to men in major cities – 47% vs 35% for IRPC (P<0.001), and 78% vs 71% for HRPC (P<0.001). Men from highest SES quintiles were less likely to have ADT (30% for IRPC and 63% for HRPC) compared to the remaining four quintiles (P<0.001). Men treated in private institutions were less likely to have ADT compared to public institutions – 33% vs 47% for IRPC (P<0.001), and 71% vs 80% (P<0.001). In multivariable analyses, age, PSA at diagnosis, clinical T stage, ISUP grade group, jurisdictions, area of residence, SES and treatment centres remained significantly associated with ADT use. Men with IRPC who lived in inner regional areas were 1.51 times (95%CI=1.26-1.80) more likely to have ADT with RT compared men with IRPC who lived in major cities. Men from highest SES quintiles were less likely to have ADT with RT compared those from lowest SES quintiles –OR=0.69 (95%CI=0.54-0.87; P=0.002) in men with IRPC and OR=0.72 (95%CI=0.55-0.95; P=0.02) in men with HRPC. Men treated in private institutions were also less likely to have ADT with RT compared to men treated in public institutions – OR=0.50 (95%CI=0.43-0.59; P<0.001) for IRPC and OR=0.59 (95%CI=0.49-0.71; P<0.001).

Conclusion:

This is the largest contemporary Australasian series evaluating the pattern of ADT use with RT. We showed that more than half of men with IRPC and one quarter of men with HRPC did not have ADT with RT. There is notable variations in practice at a population-based level. Future effort is needed to identify enablers and barriers of combining ADT with prostate RT, especially in men with HRPC.

Keywords: radiotherapy, androgen deprivation, registry

407

Digital Poster

Stereotactic magnetic resonance-guided online adaptive radiotherapy in kidney oligometastases

Mohamed LAOUITI 1 , zohra MAZOUNI 1 , Emanuela SALATI 2 , Anna Durigova 2

1 Radiation-Oncology, HRC (Hopital Riviera Chablais), Rennaz, Switzerland. 2 Medical-Oncology, HRC (Hopital Riviera Chablais), Rennaz, Switzerland

Purpose/Objective:

To assess the feasibility of Stereotactic Body Radiotherapy (SBRT) using the Elekta 1.5T MRI linear accelerator (MR Linac) for the treatment of kidney metastasis in two patients with oligometastatic lung carcinoma.