ESTRO meets Asia 2024 - Abstract Book

S350

Physics – Radiomics, functional and biological imaging and outcome prediction

ESTRO meets Asia 2024

443

Proffered Paper

Exploring Impact of Dose Deposition and Breast Composition on Acute Breast Oedema after Radiotherapy

Tanwiwat Jaikuna 1,2 , David Azria 3 , Jenny Chang-Claude 4,5 , Maria Carmen De Santis 6 , Sara Gutiérrez-Enríquez 7 , Marcel van Herk 1 , Peter Hoskin 1 , Maarten Lambrecht 8 , Petra Seibold 4 , Alejandro Seoane 9 , Elena Sperk 10 , R Paul Symonds 11 , Christopher J Talbot 11 , Tiziana Rancati 12 , Tim Rattay 11 , Victoria Reyes 13 , Barry S Rosenstein 14 , Dirk de Ruysscher 15 , Ana Vega 16 , Liv Veldeman 17 , Adam Webb 18 , Catharine M L West 1 , Eliana Vasquez Osorio 1 , Marianne C Aznar 1 1 Radiation Related Research, The University of Manchester, Manchester, United Kingdom. 2 Radiology, Mahidol University, Bangkok, Thailand. 3 Radiation Oncology, Montpellier Cancer Institute, Université Montpellier, Montpellier, France. 4 Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 5 University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 6 Radiation Oncology, Fondazione IRCCS Isituto Nazionale dei Tumori, Milan, Italy. 7 Hereditary Cancer Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. 8 Radiation Oncology, KU Leuven, Leuven, Belgium. 9 Medical Physics, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. 10 Radiation Oncology, Mannheim Cancer Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 11 Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom. 12 Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 13 Radiation Oncology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus,, Barcelona, Spain. 14 Radiation Oncology, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai,, New York, USA. 15 Maastricht University Medical Center, Department of Radiation Oncology (Maastro Clinic),, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands. 16 Fundacion Publica Galega Medicina Xenomica, Universitario de Santiago, Santiago, Spain. 17 Radiation Oncology, Ghent University Hospital, Ghent, Belgium. 18 Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom

Purpose/Objective:

Breast oedema is a side effect that can occur following breast radiotherapy, arising from the inability of fluid to drain in the duct or interstitial tissue and can negatively affect the patient’s physical and psychological health. However, breast composition, i.e. the distribution of fat and fibroglandular tissue within the breast, varies between patients. Here, we assess the feasibility of assessing dose to fibroglandular tissue and fat separately and investigate the correlation between dose deposition in different tissues with the observed rate of acute breast oedema after radiotherapy.

Material/Methods:

Data from 922 early-stage breast cancer patients who underwent breast-conserving surgery and radiotherapy between 2014 and 2017 in the multi-centre REQUITE study (www.requite.eu) were included. The severity of breast oedema was prospectively assessed immediately after radiotherapy completion. Clinicians evaluated the severity of acute breast oedema following the Common Terminology Criteria for Adverse Events (CTCAE) v4.0, and patients answered the BR23 questionnaire developed by the European Organisation for Research and Treatment of Cancer. A maximum severity score of acute oedema, combining clinician and patient scores, was selected for analysis.