ESTRO meets Asia 2024 - Abstract Book

S52

Interdisciplinary – Biomarkers

ESTRO meets Asia 2024

standardize the findings as per the customized field for every patient, the mean DC yield per cm 2 of irradiated area was calculated. Data of the study proforma was entered into Microsoft Excel to create a comprehensive Master Chart. Statistical analysis was performed on SPSS Version 25 software running on Windows/ Mac OS. The mean & standard deviation in yield of DCs, for different radiation points, was calculated and compared for statistical difference. Students’ t-test (parametric) or Mann Whitney U test (non-parametric) for quantitative variable and Chi Square test for qualitative variable were applied to test for statistical significance, if any.

Results:

The mean yield of DC/cm 2 in the CTRT group was greater than the RT alone group by 35.77%, 19.42%, and 13.93% in Week 1, Week 2, and Week 3 of treatment respectively. This difference between the two groups at Week 1 (p=0.003), week 2 (p=0.02) was found to be statistically significant. However, at week 3 this difference tended toward statistical non-significance (p=0.07).

Conclusion:

There is a dose-dependent increase in the yield of DCs in lymphocytes of HNC patients undergoing RT with subsequent fractions. Our study bio-dosimetrically proves that Cisplatin based chemoradiation results in significantly increased response to radiation, especially in the first two weeks of the treatment course.

Keywords: Biodosimetry, Dicentric Assay, Radiosensitisation